Leuprolide Acetate / Norethindrone Acetate
Lupaneta Pack is considered experimental and investigational for all other indications including the following :
- Abnormal uterine bleeding
- concomitant use with other LHRH agents
Lupaneta Pack is considered not medically necessary for persons with the following contraindications to its use:
- Females who are pregnant or lactating
- Persons with a known or history of breast or other hormonesensitive cancer
- Persons with thrombotic or thromboembolic disorders
- Persons with liver tumors or liver disease.
What To Do In Case Of Overdose
If you think youve been given too much of this drug, call your doctor. You can also call the American Association of Poison Control Centers at 800-222-1222 or use its online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.
The following information is provided for clinicians and other healthcare professionals.
Will Trelstar Lower My Testosterone Level
Yes, it will. One of the primary goals of prostate cancer treatment is to lower peoples testosterone level. This is because prostate cancer grows and spreads when its exposed to testosterone. When testosterone levels are reduced, prostate cancer tumors may shrink in size or even go away completely. This in turn helps to relieve symptoms of the condition.
In clinical studies, Trelstar was found effective in lowering testosterone levels in people with advanced prostate cancer. See the section Trelstar Uses above for more details.
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Is Eligard A Chemotherapy Drug
No, Eligard isnt a chemotherapy drug. Chemotherapy drugs work throughout the body to decrease the number of cancer cells a person has. However, because chemotherapy drugs work throughout a persons body, they often have many side effects.
Eligard is a type of hormone therapy. It works by decreasing the amount of testosterone that you have. Testosterone helps prostate cancer cells grow. Therefore, decreasing the amount of testosterone that you have decreases the growth of your prostate cancer. This in turn helps decrease symptoms caused by the cancer.
For more on how Eligard helps to manage symptoms of advanced prostate cancer, see the How Eligard works section below. If you have additional questions about how Eligard works, talk with your doctor.
* Use of the terms male and female within this article refers to a persons sex assigned at birth.
How Much Does Lupron Depot Cost With Insurance
Every specific insurance drug plan is unique and may or may not cover Lupron Depot . The cost of Lupron Depot with insurance coverage varies depending on your plan – check with your insurance provider for particular formulary coverage and coinsurance information. If your plan does not cover Lupron Depot , you can use a SingleCare card to get discounts on Lupron Depot at your neighborhood pharmacy. In addition, you can also use SingleCare savings if you have Medicare or Medicaid. In the event that Medicare or Medicaid dont completely cover your Lupron Depot medication, use SingleCare instead. Go to the SingleCare website or app to review the lowest price of Lupron Depot with SingleCare versus your price with insurance or Medicare.
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How Do Prostap Injections Work
Prostap injections contain the active ingredient leuprorelin acetate, which is a type of medicine known as a gonadorelin analogue. It’s similar to a natural hormone called gonadotropin releasing hormone . GnRH acts on the pituitary gland in the brain, causing production of testosterone in men and oestrogen in women.
Leuprorelin acts on the pituitary gland in the same way as natural GnRH. It initially increases the production of testosterone and oestrogen, but with continued treatment it desensitises the pituitary gland. This stops the production of testosterone in men and oestrogen in women.
The growth of most prostate cancers is stimulated by testosterone. Leuprorelin deprives the tumour of testosterone, causing it to stop growing or shrink.
Endometriosis and fibroids
The growth of endometriotic tissue and uterine fibroids is stimulated by oestrogen. By stopping oestrogen production, leuprorelin brings on a temporary menopause that deprives these tissues of oestrogen and causes them to stop growing or shrink.
Because of its effect on body hormones, leuprorelin can be used to treat hormone responsive early stage breast cancer in pre and perimenopausal women at higher risk of recurrence, and hormone responsive advanced breast cancer in pre and perimenopausal women.
Side Effects And Risks
Lupron Depot and Eligard both contain leuprolide acetate. Therefore, these medications can cause similar side effects. Below are examples of these side effects.
Mild side effects
These lists contain examples of mild side effects that can occur with Lupron Depot , with Eligard, or with both drugs .
- Can occur with Lupron Depot:
- body pain
Serious side effects
These lists contain examples of serious side effects that can occur with Lupron Depot or with both drugs .
- Can occur with Lupron Depot:
- high blood sugar that may lead to new or worsening type 2 diabetes
- cardiovascular problems, such as heart attack, sudden death, or stroke
- problems with your hearts electrical activity, such as long QT syndrome
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Eligard For Prostate Cancer
The Food and Drug Administration approves prescription drugs such as Eligard to treat certain conditions. Eligard may also be used off-label for other conditions. Off-label drug use means using a drug for a purpose other than what its been approved for by the FDA.
Eligard is approved for use as a palliative treatment for advanced prostate cancer in adult males*. Palliative treatment means that the drug works to help manage pain and other symptoms of this condition. It wont treat or cure advanced prostate cancer, but it may help improve a persons quality of life.
* Use of the terms male and female within this article refers to a persons sex assigned at birth.
Lupron For Prostate Cancer
Prostate cancer is a serious health problem, but it is also manageable.
Various therapies and treatment approaches are available to tackle this common disease.
One of these therapies for prostate cancer is the use of Lupron.
If youve ever wanted to know about Lupron and how it works, you came to the right place.
Read on to learn more about this therapy and whether its effective in the first place.
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Lupron Depot And Other Medications
There havent been any studies done to look at whether Lupron Depot can interact with other medications. However, its possible that Lupron Depot may interact with other medications.
Before taking Lupron Depot, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
What Does Lupron Depot Cost
Costs of prescription drugs can vary depending on many factors. These factors include what your insurance plan covers and which pharmacy you use. To find current prices for Lupron Depot in your area, visit WellRx.com.
If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. A program called myAbbVie Assist may also be available to help with the cost Lupron Depot.
To learn more about saving money on prescriptions, you can also check out this article.
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Trelstar For Advanced Prostate Cancer
Trelstar is FDA-approved for palliative treatment of advanced prostate cancer in adult males. With palliative treatment, symptoms of your condition are reduced to help improve your quality of life. Trelstar isnt meant to cure prostate cancer.
With advanced prostate cancer, the cancer has spread from your prostate to other areas of your body. This is also called metastatic prostate cancer. Prostate cancer commonly spreads to other organs in your pelvis and your bones. This can lead to bothersome symptoms, such as urinary and bowel issues, and pain and discomfort in the areas affected by the cancer.
Trelstar contains the drug triptorelin. It belongs to a class of medications called gonadotropin-releasing hormone agonists. This class of drugs falls into a larger category of prostate cancer drugs called hormone therapy.
Hormone therapy works by stopping your body from making the hormone testosterone, or by blocking the activity of testosterone. These actions help to stop the growth and spread of prostate cancer in your body. This in turn helps to relieve your symptoms of the condition.
Effectiveness for advanced prostate cancer
Trelstar was evaluated for its effectiveness in three separate clinical studies, which included 428 men with advanced prostate cancer. In these studies, the men received three different doses of Trelstar as follows:
These studies looked at how many men reached and stayed in medical castration with treatment.
How Should This Medicine Be Used
Leuprolide injection comes as a long-acting suspension that is injected intramuscularly by a doctor or nurse in a medical office or clinic and is usually given once a month or every 3, 4, or 6 months . Leuprolide injection also comes as a long-acting suspension that is injected subcutaneously by a doctor or nurse in a medical office or clinic and is usually given every 1, 3, 4, or 6 months. Leuprolide injection also comes as a long-acting suspension that is injected subcutaneously by a doctor or nurse in a medical office or clinic and is usually given every 6 months. Your doctor will tell you how long your treatment with leuprolide injection will last. When used in children with precocious puberty, leuprolide injection will likely be stopped by your child’s doctor before 11 years of age in girls and 12 years of age in boys.
If you receive leuprolide long-acting suspension as a subcutaneous injection, you may notice a small bump at the place where the injection was given when you first receive the medication. This bump should eventually go away.
Leuprolide may cause an increase in certain hormones in the first few weeks after injection. Your doctor will monitor you carefully for any new or worsening symptoms during this time.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
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Lupron Depot And Pregnancy
Lupron Depot should not be used by people who are pregnant or planning to become pregnant. Lupron Depot may cause harm to a developing fetus if used during pregnancy. In animal studies, Lupron Depot was given to pregnant rabbits. It caused negative side effects in the offspring . This was true even at very low doses.
Leuprolide, the active ingredient in Lupron Depot, is sometimes prescribed off-label for people who are undergoing fertility treatments. Its used as part of a complex hormone treatment plan that includes other medications. Lupron Depot should be used for this purpose only as recommended by your doctor.
Dosage For Prostate Cancer
Eligard is approved only for palliative treatment* of advanced prostate cancer in adult males. Its given as a subcutaneous injection by a healthcare professional.
How often you get an injection of Eligard depends on your dose of the drug. The lower the dose, the more frequent the injections. The following table lists how often youll receive injections of Eligard based on dose:
|45 mg||once every 6 months|
Despite the dosage differences, each dose of Eligard is designed to give you 7.5 mg of the drug per month. It does this by releasing a small amount of the drug into your body over time. This ensures that you have a consistent amount of medication in your body from one dose to the next.
* Palliative treatment means that the drug works to help manage pain and other symptoms of this condition. It wont treat or cure advanced prostate cancer, but it may improve a persons quality of life. Use of the terms male and female within this article refers to a persons sex assigned at birth.
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How To Use Lupron Solution
Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start using leuprolide and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
This medication is given by injection under the skin as directed by your doctor, usually once a day.
In children, the dosage is based on weight and response to treatment. The doctor should consider stopping treatment before age 11 for girls and age 12 for boys. Consult the doctor for details.
If you are using this medication at home, learn all preparation and usage instructions from your health care professional and the product package. Learn how to store and discard medical supplies safely.
Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin.
Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each day.
During the first few weeks of treatment, your hormone levels will actually go up before they go down. This is a normal response to this medication. Your symptoms may get worse for a few weeks.
Dosage For Central Precocious Puberty
For central precocious puberty, Lupron Depot-Ped can be given as a once-monthly dose thats based on body weight:
- 7.5 mg for children 55 lb or less
- 11.25 mg for children more than 55 lb up to 83 lb
- 15 mg for children more than 83 lb
Lupron Depot-Ped can also be given once every 3 months. The dosage options for taking it every 3 months are 11.25 mg or 30 mg.
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Drugs Used With Lupron Depot For Palliative Treatment Of Advanced Prostate Cancer
When treating advanced prostate cancer, Lupron Depot is often used with other drugs to reduce the risk of a tumor flare. These drugs are called anti-androgen medications.
Lupron Depot works by stopping your body from making certain hormones, like testosterone. When you first start taking Lupron Depot, your body may respond by producing too much testosterone. This can have negative side effects such as bone pain and paralysis. Lowering the risk of a testosterone flare can help lower your risk for these side effects.
Anti-androgen medications can be given with Lupron Depot or before you start Lupron Depot. Examples of these medications include bicalutamide , nilutamide , and flutamide .
Here are answers to some frequently asked questions about Lupron Depot.
Treatment By Stage Of Prostate Cancer
Different treatments may be recommended for each stage of prostate cancer. Your doctor will work with you to develop a specific treatment plan based on the cancers stage and other factors. Detailed descriptions of each type of treatment are provided earlier on this same page. Clinical trials may also be a treatment option for each stage.
Early-stage prostate cancer
Early-stage prostate cancer usually grows very slowly and may take years to cause any symptoms or other health problems, if it ever does at all. As a result, active surveillance or watchful waiting may be recommended. Radiation therapy or surgery may also be suggested, as well as treatment in clinical trials. For those with a higher Gleason score, the cancer may be faster growing, so radical prostatectomy and radiation therapy are often recommended. Your doctor will consider your age and general health before recommending a treatment plan.
ASCO, the American Urological Association, American Society of Radiation Oncology, and the Society of Urologic Oncology recommend that patients with high-risk early-stage prostate cancer that has not spread to other areas of the body should receive radical prostatectomy or radiation therapy with hormonal therapy as standard treatment options.
Locally advanced prostate cancer
Watchful waiting may be considered for older adults who are not expected to live for a long time and whose cancer is not causing symptoms or for those who have another, more serious illness.
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What Is Lupron Depot Used For
Lupron Depot and Lupron Depot-Ped are a type of hormone therapy. This medication belongs to a group of drugs called gonadotropin-releasing hormone agonists.
GnRH agonists work by activating the pituitary gland in your brain to release certain hormones. In turn, these hormones cause your reproductive system to release a surge of sex hormones.
This surge signals your body to stop making the sex hormones. Ultimately, in males, Lupron Depot causes the testicles to stop making testosterone. And in females, the drug causes the ovaries to stop making estrogen and progesterone.
Lupron Depot and Lupron Depot-Ped are used to treat certain conditions that may improve when the body stops making these hormones. These conditions are described below.
* In this article, we use the terms male and female to refer to someones sex assigned at birth. For information about the difference between sex and gender, see this article.
Can I Take Lupron Depot If I Have Heart Disease
Possibly. Lupron Depot may raise your risk of having a heart attack or experiencing sudden death or a stroke. This risk is higher in people who have existing heart disease. If you already have heart disease, your doctor will likely evaluate your condition before prescribing you Lupron Depot. If youre able to take Lupron Depot, theyll monitor you closely during your treatment to make sure your heart problems dont get worse.
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