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Prostate Biopsy Side Effects Pros And Cons

Biopsy During Surgery To Treat Prostate Cancer

Pros and Cons of Perineal vs. TRUS-Guided Prostate Biopsies

If there is more than a very small chance that the cancer might have spread , the surgeon may remove lymph nodes in the pelvis during the same operation as the removal of the prostate, which is known as a radical prostatectomy .

The lymph nodes and the prostate are then sent to the lab to be looked at. The lab results are usually available several days after surgery.

Mpmri Combined With Trus In Fusion

mpMRI has also shown significant promise when combined with TRUS through fusion biopsy. Fusion biopsy combines mpMRI imaging with ultrasound during the biopsy procedure, enabling live visualization of suspicious lesions. The additional imaging provided by mpMRI enables targeted biopsies, which refer to intentionally sampling a suspicious lesion suspected to contain csPCa, to be conducted.

Substantial research indicates that fusion biopsies have higher rates of csPCa detection compared to standard TRUS biopsy. Siddiqui et al report that fusion-targeted biopsy increases detection of higher grade tumors by as much as 67% while reducing detection of lower grade tumors by 36% compared to traditional systematic sampling.70 Son et al report that fusion-targeted biopsy detects 3 times more cancer than systematic biopsy without fusion guidance.71 Borkowetz et al compared systematic TRUS biopsy with transperineal fusion biopsy and found fusion biopsy has a significantly higher overall cancer detection rate and detected 44% more csPCa than systematic biopsy alone.72

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How Doctors Determine Whether To Recommend A Prostate Biopsy

No two patients are alike, and a urologist needs to take many variables into account before recommending a prostate biopsy, including a patients:

  • Age and life expectancy
  • Comorbidities
  • Change in PSA values across time.

The decision of whether to undergo a prostate biopsy should be determined after an individual conversation with your doctor during which he or she presents you with the big picture of your situation.

Compare, for example, the case of two 50-year-old men: One of them has been diagnosed with heart failure and is in poor overall health. The other has no pre-existing health conditions. I probably wouldnt advise a prostate biopsy for the 50-year-old with heart failure because prostate cancer is unlikely to cause his death within the next five years.

But I would recommend that the healthy 50-year-old get a prostate biopsy, because even if his cancer isnt aggressive right now, missing a prostate cancer diagnosis may result in his death from the disease in 15 years. In his case, it would be better to risk the prostate biopsy to catch the cancer early and improve his chances of long-term survival.

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An enlarged prostate can also be the cause of other problems. If the enlarged prostate is causing symptoms, the best treatment would be a natural remedy. In the meantime, there are treatments for a wide range of conditions that cause a man to experience pain. A common surgical procedure involves an electric loop, laser, or electro-stimulation. The procedure is a safe and effective option for treating enlarged or symptomatic BPH.

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True North Testicular Cancer

  • Orchiectomy is the removal of one or both testicles due to underlying pathology. Testicular cancer, undescended testicles, or other pathologies are some of the causes that may warrant a removal of the testicle. During the testicle removal procedure one or both testis are removed without any damage to the penis or the scrotum
  • Testicular torsion: The spermatic cord can twist, displacing the testicle and potentially leading to obstruction of blood flow, which can cause loss of the testicle if not properly corrected. This condition is a surgical emergency that needs to be urgently addressed. Undescended testes: Usually diagnosed during childhood, this condition occurs when one or both testes remain in the abdomen.
  • A small incision is made in the front of the scrotum and the testicles are removed. If the cancer has already reached the bones, this is the quickest way to slow tumor growth and pain.Testosterone levels drop dramatically and the patient often has rapid relief from cancer symptoms. For sleep apnea, what are the pros/cons of the full (nose.

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Repeating The Psa Test

A mans blood PSA level can vary over time , so some doctors recommend repeating the test after a month or so if the initial PSA result is abnormal. This is most likely to be a reasonable option if the PSA level is on the lower end of the borderline range . For higher PSA levels, doctors are more likely to recommend getting other tests, or going straight to a prostate biopsy.

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Medical History And Physical Exam

If your doctor suspects you might have prostate cancer, you will be asked about symptoms you are having, such as any urinary or sexual problems, and how long you have had them. You might also be asked about possible risk factors, including your family history.

Your doctor will also examine you. This might include a digital rectal exam , during which the doctor inserts a gloved, lubricated finger into your rectum to feel for any bumps or hard areas on the prostate that might be cancer. If you do have cancer, the DRE can sometimes help tell if its only on one side of the prostate, if its on both sides, or if its likely to have spread beyond the prostate to nearby tissues. Your doctor may also examine other areas of your body.

After the exam, your doctor might then order some tests.

Should I Get A Prostate Biopsy An In

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Rising or elevated prostate-specific antigen levels, an abnormal digital rectal exam , or both, may indicate the presence of prostate cancer, and having those conditions may lead your doctor to recommend a prostate biopsy. But controversy surrounding the PSA blood test and concerns about prostate biopsies cause many patients to ask:

  • Should I get a prostate biopsy?
  • Are the risks of a prostate biopsy worth it?
  • Are there alternatives to a prostate biopsy?
  • If I have prostate cancer, is treatment necessary if Im not experiencing symptoms?

If youre looking for answers to these questions, you may find conflicting and confusing information across the medical field, in the news and on prostate cancer websites. Some dispute the necessity of prostate cancer screening and discourage men from getting a PSA test to begin with. Others suggest that prostate cancer is overtreated and that the risks associated with biopsies and treatment arent worth the potential benefit.

While the 10-year survival rate of men with a diagnosis of prostate cancer is approximately 98 percent, prostate cancer remains the second leading cause of cancer deaths in American men. The American Cancer Society estimates that 248,530 new cases of prostate cancer will be diagnosed in the United States in 2021 and that one in every 41 men diagnosed will die from the disease.

To help you better understand this topic and whether you should get a prostate biopsy, this article will cover:

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History Of Transrectal Ultrasound

The transrectal route of prostate biopsy was first described in scientific literature by Grabstald and Elliot in 1953.4 While this early technique was rudimentary, lacking any form of external guidance and using simple clamps to take bites of the prostate, it laid the foundation for the more advanced techniques practiced today. In the late 1980s, Lee and Cooner introduced the use of TRUS for guiding prostate biopsy5,6 which has been the cornerstone of prostate cancer diagnosis since. However, advancements in the field of Urology over the last several years have led physicians to consider new alternatives for increased accuracy in performing prostate biopsies and detecting clinically significant prostate cancers .

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Pros And Cons Of Transperineal Prostate Biopsy

In addition to potentially eliminating the need for antibiotics altogetheras the needle does not pass through the rectal wallthe newer method saves time instead of requiring separate appointments for both a pre-biopsy rectal swab and a subsequent biopsy once culture results are known, as is done using the TRUS system, the transperineal prostate biopsy can be completed in one in-office visit using only local anesthetic.

Duke began offering the transperineal prostate biopsy option in the clinic in October 2019, but Polascik has been performing the procedure in the operating room for the past 25 years using a cryotherapy grid. This larger transperineal prostate biopsy is done under anesthesia for the purpose of obtaining prostate tissue systematically every 5 mm, the results of which can be reconstructed into a 3-D framework of the prostate itself. Polascik gives two common reasons for why patients may opt for this larger 3-D transperineal mapping biopsy: to map out the exact size, number, and location of cancers within the prostate if interested in targeted ablation/focal therapy, and to confirm for patients in which there is still strong suspicion of having the disease, despite several rounds of conventional biopsies that have not detected prostate cancer.

If Screening Test Results Arent Normal

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If you are screened for prostate cancer and your initial blood PSA level is higher than normal, it doesnt always mean that you have prostate cancer. Many men with higher than normal PSA levels do not have cancer. Still, further testing will be needed to help find out what is going on. Your doctor may advise one of these options:

  • Waiting a while and having a second PSA test
  • Getting another type of test to get a better idea of if you might have cancer
  • Getting a prostate biopsy to find out if you have cancer

Its important to discuss your options, including their possible pros and cons, with your doctor to help you choose one you are comfortable with. Factors that might affect which option is best for you include:

  • Your age and overall health
  • The likelihood that you have prostate cancer
  • Your own comfort level with waiting or getting further tests

If your initial PSA test was ordered by your primary care provider, you may be referred to a urologist for this discussion or for further testing.

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Possible Harms From Diagnosis

Screening finds prostate cancer in some men who would never have had symptoms from their cancer in their lifetime. Treatment of men who would not have had symptoms or died from prostate cancer can cause them to have complications from treatment, but not benefit from treatment. This is called overdiagnosis.

Prostate cancer is diagnosed with a prostate biopsy. A biopsy is when a small piece of tissue is removed from the prostate and looked at under a microscope to see if there are cancer cells. Older men are more likely to have a complication after a prostate biopsy.

A prostate biopsy can cause

  • Pain.
  • Blood in the semen or ejaculate.
  • Infection.

Antibiotic Resistance And Infection Post

Polascik notes that studies show approximately 20% of men have an underlying bacterial resistance to ciprofloxacinthe recommended and most commonly used antibiotic for prostate biopsy prophylaxisdue to the frequent prescribing of the drug, making them especially susceptible to infection post-biopsy. To decrease the chance for infection post-TRUS biopsy and to determine whether a patient has a resistant organism, Dukes rectal swab culture program examines a patients rectal flora for ciprofloxacin susceptibility prior to the biopsy. If the results do not indicate susceptibility, the patient is administered another type of targeted antibiotic prophylaxis. But we have found that even with our targeted program, there is still a non-negligible infection rate, Polascik says.

Instead of using peri-procedural ciprofloxacin, Polascik notes that some practices administer a much stronger non-targeted antibiotic via intramuscular injection, while others may prescribe multiple antibiotics for prostate biopsy, which is not good antibiotic stewardship, he adds. Theres no solution thats a sure bet. By giving the best antibiotics to prevent infection, we are then potentially setting up more resistance, he says.

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Comparison Of Mri/us Fusion

Emerging evidence has shown that multiparametric magnetic resonance imaging as an innovative guidance approach for prostate biopsy increases the detection rate of prostate cancer. Hence, we also reviewed RCT studies comparing MRI/US fusion-guided biopsy and traditional systematic transrectal biopsy. This review was not included in our meta-analysis as our aim was to assess the diagnosis accuracy of transperineal and transrectal biopsy.

In the other RCT study by Kasivisvanathan et al. , the authors randomized 252 patients in an MRI-targeted group and 248 patients in a standard biopsy group. In the MRI-targeted group, 71 patients did not undergo prostate biopsy because of negative MRI results. The patients in the MRI-targeted group received a 4-core MRI/US fusion biopsy and the patients in the standard biopsy group received a systematic transrectal biopsy. Clinically significant prostate cancer was diagnosed in 38% patients in the MRI-targeted group and 26% patients in the standard biopsy group. The detection rate of the MRI-targeted biopsy is significantly higher than the traditional biopsy.

Watchful Waiting Or Active Surveillance

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Your doctor might suggest waiting to see if your tumor will grow or spread before you treat it. Most prostate cancer grows slowly. Some doctors think itâs better not to treat it unless it changes or causes symptoms. In watchful waiting, your doctor will closely track how the disease makes you feel. With active surveillance, youâll also get regular tests to check on the cancer.

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Lymph Node Biopsy As A Separate Procedure

A lymph node biopsy is rarely done as a separate procedure. Its sometimes used when a radical prostatectomy isnt planned , but when its still important to know if the lymph nodes contain cancer.

Most often, this is done as a needle biopsy. To do this, the doctor uses an image to guide a long, hollow needle through the skin in the lower abdomen and into an enlarged node. The skin is numbed with local anesthesia before the needle is inserted to take a small tissue sample. The sample is then sent to the lab and looked at for cancer cells.

Mpmri Prostate And Targeted Biopsy

The use of pre-biopsy mpMRI may aid in the detection of clinically significant prostate cancer . The PRECISION study randomised men to undergo either systematic or targeted biopsies and suggested that targeted biopsy was more sensitive for the detection of clinically significant prostate cancer . MRI-FIRST studied 251 men who received mpMRI followed by both targeted and systematic TRUS biopsies. The rate of clinically significant prostate cancer was higher when both targeted and systematic biopsies were performed, and each technique would have missed lesions if performed alone . Systematic biopsy ensures the thorough diagnostic assessment of the prostate allowing for the limitations of mpMRI and cognitive fusion using TRUS.

Although mpMRI is typically reliable for identifying higher-grade tumours , it does have limitations. Up to 16% of clinically significant lesions can be missed, resulting in a false negative diagnosis . Therefore, a decision to abandon biopsy based on negative mpMRI results should be limited to high-volume uro-radiological units with extensive operator experience. A significant proportion of the tumours missed on mpMRI will be in the peripheral zone, which is well sampled by TRUS biopsy. Many healthcare systems do not have the resources required to provide routine pre-biopsy mpMRI or fusion software for targeting lesions, thus maintaining the relevance of TRUS biopsy.

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Prostate Biopsy Side Effects Pros And Cons

The only other thing I was drinking in the first 6 months after my diagnosis was green tea. I would drink about 4 glasses of green tea daily to go along with the increased water intake. I wasnt putting any other liquid into my body for the first 6 months. This was a big help in starting my road to recovery.

Once I started feeling better then I added organic soy milk to my diet as well. Soy milk isnt much like regular milk but once you get used to it then its not bad at all. To this day these are the only 3 liquids I have in my diet. To recap the 3 liquids I drink today are purified water,green tea,& organic soy milk. I put no other liquids into my body period.

Now, I want to chat a little more about meat & other aspects of a proper diet. As I said we dont need meat to live. I thought cutting or limiting meat in my diet would be to hard to accomplish. Well again my thinking was wrong. Was it easy? No! However, after a couple weeks then things were starting to get easier. I didnt cut all meats out of my diet but I did cut certain meats & eat moderate amounts of all others.

One meat that needs to be completely cut or at least very minimized is red meat . Too much Red meat consumption is not good for prostate health. I was eating a lot of fast food burgers & also red meat at home. I will say to at least cut red meat completely out of your diet until you get your prostate health back.


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