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A new treatment to be used in combination with radiotherapy that could significantly improve treatment outcomes for men with locally advanced prostate cancer.
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Researchers in Japan have demonstrated a new antibody treatment for prostatecancer. The drug helps reverse a nasty trick that cancer cells play on the immune system, with promising results shown.
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Stage 3 treatment. Stage 3 prostatecancer involves a tumor that’s grown and is locally advanced. Stage 3 is also divided into 3A, 3B and 3C. The higher the stage, the more it’s spread to nearby structures such as the seminal vesicles, the bladder and rectum. In stage 3, cancer cells look different from healthy prostate cells.
TUESDAY, Jan. 18, 2022 — Advanced forms of hormone therapy are very effective at keeping prostatecancer in check, but they also can double a man’s risk of falling into depression,.
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Men’s Health Newtreatment approved for late-stage prostatecancer April 7, 2022 By Charlie Schmidt, Editor, Harvard Medical School Annual Report on Prostate Diseases In late March, the FDA approved a new therapy for advanced prostatecancer that is metastasizing, or spreading, in the body.
Treating Advanced Prostate Cancer
If the cancer has reached an advanced stage, it’s no longer possible to cure it. But it may be possible to slow its progression, prolong your life and relieve symptoms.
Treatment options include:
- hormone treatment
If the cancer has spread to your bones, medicines called bisphosphonates may be used. Bisphosphonates help reduce bone pain and bone loss.
Prostate Cancer Treatment Advances: Can They Help You
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While the 10-year survival rate for men diagnosed with prostate cancer in the United States is approximately 98 percent, many men face difficult decisions about their treatment options. They worry not only about which treatment may be appropriate in fighting their cancer, but also about the impact treatment may have on their quality of life.
In 90 percent of cases, prostate cancer is diagnosed at the local or regional stage, meaning it hasnt spread beyond the prostate or nearby organs. Men diagnosed with early-stage prostate cancer may have several treatment options with similar outcomes. Men diagnosed with distant cancer, meaning its already spread to other areas of the body, face different treatment decisions. Either way, its normal to feel anxious after a diagnosis and to want to take action right away.
But you may regret rushing into a treatment plan without considering your options carefully. Prostate cancer treatment has common side effects, especially urinary incontinence and erectile dysfunction, that may negatively impact your quality of life. Because prostate cancer often progresses slowly, most men have time to investigate their options.
Whether youre already receiving treatment for prostate cancer, or youre considering new treatment decisions, its worth learning about prostate cancer treatment advances that may affect your choices.
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The Robotic approach uses robotic technology to mimic the surgeon’s movements. This surgery requires multiple tiny incisions. It also offers more precision, as it lets your doctor see the prostate in 3-D and magnifies everything 10 times.
Lung and Bronchus Prostate Breast Colon and Rectum Pancreas Top 5 Fatal Cancers in Vermont per 100,000 Population Note: All rates are age-adjusted.
Cancer Research UK.
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Diagnostic Advances In Prostate Cancer
Prostate cancer diagnosis is followed by staging of the cancer. If theres no evidence of metastasis of the original prostate tumor, meaning the cancer hasnt spread to other parts of the body, your cancer will also be assigned to a risk stratification group, also known as a risk group. The risk group attempts to predict the likelihood that the disease has spread microscopically outside the prostate. We informally refer to three risk groups: low risk, intermediate risk and high risk, although as many as six different groups exist.
The specific stage and/or risk stratification of your cancer may determine your treatment options. In general:
Depending on your specific diagnosis, you may have two or more good treatment choices that have similar outcomes, and you probably have time to investigate those options.
Recent areas of advancement in oncology may provide a more accurate picture of your specific diagnosis, directing you and your doctor to more appropriate treatment options. Two specific developments include prostate-specific PET scan agents that may allow us to get more accurate imaging than we could before and the results of advanced genomic testing, which may help identify more aggressive cancers that are less suitable for active surveillance.
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How Psma Lights Up Cancer Cells
In 2021, the U.S. Food and Drug Administration issued national approval to two new prostate cancer imaging tests based on similar technology. On a PET scan, the test lights up the cancerous cells that would otherwise be hidden, enabling doctors to precisely target treatment.
Both advances in imaging and therapy rely on targeting PSMA, which is not found on most normal cells but is overexpressed in cancer cells, especially those that have spread. The PSMA molecule was cloned at MSK in the early 1990s.
The Molecular Imaging and Therapy Service, led by Heiko Schöder, played a key role in the development and testing of a slightly different PSMA-directed imaging technology at MSK.
This advance is the result of years of work by the community of physicians promoting the use of PSMA agents, Dr. Schöder says. Its gratifying to see a collaborative effort result in a breakthrough that has the potential to make a difference for so many patients with advanced prostate cancer.
Before receiving the therapy, patients in the VISION trial were scanned with PSMA-directed PET imaging to make sure enough PSMA was present in the cells to make them likely to respond to the treatment. If so, they received the radioactive drug by injection over four to six sessions, spaced six weeks apart.
As a next step, Dr. Morris and colleagues are looking into using the PSMA-directed therapy earlier rather than only after the prostate cancer has spread.
Michael Morris
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This new“PSMA PET” scan can detect prostate cancer metastases much earlier, when they are much smaller, which may help to improve treatment of patients with prostate cancer. PSMA, short for Prostate Specific Membrane. … The actor and comedian previously received treatment for. Apr 12, 2022· Imaging Techniques To Detect Bladder Cancer.
Hinova Pharmaceuticals Inc., a clinical-stage biopharmaceutical company focused on developing novel therapeutics for cancers and metabolic diseases through targeted protein degradation.
Researchers continue to look for foods that can help lower prostate cancer risk. Scientists have found some substances in tomatoes and soybeans.
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Queen’s researcher awarded £280,000 to develop newprostatecancertreatment 31 August, 2022. A researcher at Queen’s University Belfast has been awarded over £280,000 from ProstateCancer UK to develop the first-ever personalised radiotherapy treatment for advanced prostatecancer based on men’s genes.
Basel, March 23, 2022 Novartis announced today that the US Food and Drug Administration approved Pluvicto TM for the treatment of adult patients with a certain type of advanced cancer called prostate-specific membrane antigen-positive metastatic.
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New Targeted Radiation Treatment Effective Against Metastatic Castration
Who does this study affect: People with metastatic castration-resistant prostate cancer that has not been stopped by treatment with androgen inhibitors and taxane chemotherapy.
What did this study find: The phase 3 VISION clinical trial has shown that a targeted radiation treatment called lutetium-177-PSMA-617 added to current standard treatments slows the progression of mCRPC for about 5 months longer than the current standard of care and helps people live about 4 months longer than the current standard of care.
When the growth of advanced prostate cancer is no longer slowed by low testosterone levels in the body and the cancer has spread to other parts of the body, it is called mCRPC. There is no cure for mCRPC, and it can be difficult to treat. Currently, ASCO recommends treatment that continues to lower hormone levels in the body as well as androgen inhibitors, such as abiraterone acetate or enzalutamide , and chemotherapy with docetaxel , as well as other treatments.
After a median follow-up of nearly 21 months, the researchers saw that the cancer was stopped for a median of 8.7 months in the 177Lu-PSMA-617 group, compared with a median of 3.4 months in the control group. In terms of overall survival, people in the 177Lu-PSMA-617 group lived for a median of 15.3 months, compared with a median of 11.3 months in the control group.
lead study author Michael J. Morris, MDMemorial Sloan Kettering Cancer CenterNew York, New York
Active Surveillance For Prostate Cancer
Active surveillance is a plan to monitor low and some intermediate-risk, localized prostate cancer. If, among other criteria, your cancer has not spread beyond the prostate, is not causing symptoms and does not show signs that it may be aggressive, active surveillance may be an appropriate option for you.
Why would you consider active surveillance over immediate, more aggressive treatment like surgery or radiation therapy? It comes down to carefully weighing risks versus quality of life.
We know that, in most men, prostate cancer grows slowly. In some cases, it may take three to 10 years to reach the point where it needs to be treated. In the meantime, if you can safely postpone treatment, you can avoid the sometimes-immediate and long-term side effects that may have serious consequences on your quality of life.
Having access to some of the advances in prostate cancer treatment discussed earlier in this article may allow you to choose active surveillance with more confidence. For example, if genomic testing predicts that your cancer is not aggressive, and/or a prostate-specific PET scan finds no evidence of cancer cells outside of the prostate, active surveillance may be the right choice for you.
Active surveillance does not mean that we ignore the cancer. If you and your care team decide its an appropriate option for you, your urologist will monitor your disease with regular follow-ups, which may include:
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An Increase In Available Drug Options
While LuPSMA isnt yet on the market, the sheer number of new medications already available for advanced prostate cancer has been a major research boon in recent years. The proliferation of medications within the advanced prostate cancer space has significantly increased the options available to the treating provider, Dr. Haywood says. Since the time I started urology training, several medications targeting the androgen hormone axis have been approved, resulting in significant expansion of the options available to men with advanced prostate cancer. More on those next.
New Hormone Therapy Drugs
Testosterone drives prostate cancer growth, so medications often target it, says Timothy Daskivich, M.D., urologic oncologist at Cedars-Sinai Cancer in Los Angeles, CA. For many years, patients who progressed on traditional androgen deprivation therapy had few options other than chemo, he says. But new androgen receptor signaling inhibitors can provide excellent cancer control and responses in those patients and have shown improved survival chances in patients with metastatic and castration-sensitive disease when given in conjunction with traditional hormone blockade. These new drugs include abiraterone acetate, apalutamide, enzalutamide, and Orgovyx , the only androgen-deprivation therapy that comes in pill form.
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ProstateCancer UK is a registered charity in England and Wales and in Scotland . Registered company number 02653887. Registered office: Fourth floor, The Counting House, 53 Tooley Street, London SE1 2QN.
Cryotherapy Cryotherapy is a treatment that uses extreme cold to freeze and destroy cancer cells. It is also known as cryosurgery or cryoablation. Thin needles are inserted.
Surgery is one of the main treatments for prostatecancer. You usually have a radical prostatectomy. This means removing the whole of the prostate gland. Hormone therapy for prostatecancerProstatecancer usually depends on testosterone to grow. Hormone therapy blocks or lowers the amount of testosterone in the body.
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After non-melanoma skin cancer, prostatecancer is the most common cancer in American men. It’s also highly treatable if your doctor spots it early. For many men, though, the standard treatments ….
Early-stage prostate cancer is very treatable with surgery, radiation, and other options. Find out more from the experts at WebMD. When youre diagnosed with prostate cancer at an early.
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Early-stage prostate cancer is very treatable with surgery, radiation, and other options. Find out more from the experts at WebMD. When youre diagnosed with prostate cancer at an early.
Prostatecancertreatments vary: From newer techniques like cryotherapy, to surgery, hormone therapy and more. Learn about prostate cancer treatment, and care, here..
Combining Existing Treatments Can Improve Survival In Men With Localised And Advanced Prostate Cancer
Results from two major trials could change the way we treat prostate cancer. We look at what these findings mean for men and their families.
As well as developing new treatments, another way were trying to speed up progress against prostate cancer is by trialling existing treatment combinations at different stages of the disease.
Two exciting trials in this area, STAMPEDE and PEACE-1, had results presented by researchers at the ESMO annual conference, and the great news is that both have shown significant benefit compared to standard treatments.
STAMPEDE trial: new combinations to treat aggressive, localised prostate cancer
Abiraterone is a drug thats currently only used once cancer has spread and is not responding to other hormone therapies. But the latest results from the STAMPEDE trial show that giving abiraterone to men with localised disease thats at high-risk of spreading, significantly reduced the number of men whose cancer did spread, and crucially, reduced the number who died from prostate cancer within six years by more than half .
Once the final resultsare published, we hope to see abiraterone made available to these men much earlier in their treatment.
Dr Matthew Hobbs, Director of Research at Prostate Cancer UK, said: Too many men are dying from prostate cancer, and it is vital that we find new ways to help prevent it from spreading and becoming lethal.
PEACE-1 trial: new combinations to treat advanced prostate cancer
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What Are Some Emerging Therapies For Prostate Cancer
Because prostate cancers can act so differently, they need different types of treatment. New research is focusing on precision medicine. The goal is to have tailored treatment for each person from the very beginning. Since there are so many different types of prostate cancer, precision medicine needs to cover a lot of bases. Its important to remember that not all emerging therapies are right for everyone. And the FDA hasnt approved some of these treatments yet. If you have advanced prostate cancer, talk to your team about whether you should try these emerging therapies:
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PARP inhibitors: These medications stop prostate cancers from growing. They can help people with metastatic prostate cancer who have mutations in their BRCA1, BRCA2, and DDR genes.
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Prostate membrane-specific antigen radionuclide therapy: PSMA radionuclide therapy delivers radiation directly to prostate cancer cells. A recent study showed that people with metastatic prostate cancer who received this therapy lived longer.
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Focal therapies: Focal therapies use heat, cold, or electricity to kill cancer cells in the prostate gland and limit damage surrounding tissues. Therapies include focal irreversible electroporation, high-intensity focused ultrasound, cryotherapy, and focal laser ablation. These therapies are still investigational .
Chemotherapy For Prostate Cancer
Patients who no longer respond to hormone therapy have another option.
The chemotherapy drug docetaxel taken with or without prednisone is the standard chemotherapy regimen for patients who no longer respond to hormone therapy. Docetaxel works by preventing cancer cells from dividing and growing. Patients receive docetaxel, along with prednisone, through an injection. Side effects of docetaxel are similar to most chemotherapy drugs and include nausea, hair loss, and bone marrow suppression . Patients may also experience neuropathy and fluid retention.
Docetaxell, when used with or without prednisone, was the first chemotherapy drug proven to help patients live longer with advanced prostate cancer. The average survival was improved by about 2.5 months when compared to mitoxantrone with or without prednisone. Docetaxel has the best results when given every three weeks as compared to weekly dosing.
Cabazitaxel is another chemotherapy drug, used in combination with the steroid prednisone, to treat men with prostate cancer. Cabazitaxel is used in men with advanced prostate cancer that has progressed during, or after, treatment with docetaxelâââââââ .
Side effects in those treated with cabazitaxel included significant decrease in infection-fighting white blood cells , anemia, low level of platelets in the blood , diarrhea, fatigue, nausea, vomiting, constipation, weakness, and renal failure.
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Treating Prostate Cancer That Has Spread To The Bones
Doctors are studying the use ofradiofrequency ablation to help control pain in men whose prostate cancer has spread to one or more areas in the bones. During RFA, the doctor uses a CT scan or ultrasound to guide a small metal probe into the area of the tumor. A high-frequency current is passed through the probe to heat and destroy the tumor. RFA has been used for many years to treat tumors in other organs such as the liver, but its use in treating bone pain is still fairly new. Still, early results are promising.