How Long Does Prostate Cancer Take To Spread

How Long Does It Take Prostate Cancer To Develop

It could take virtual ages for prostate cancer to develope? anywhere from five to ten years, and even more or it could take between a mere couple of months and two or three years. One of the worst things about prostate cancer is that there are yet many answers that are elusive concerning the malignancy, resulting in several more questions than there are answers to them. The thing is that the rate of prostate cancer growth and spread varies from man to man, so that one overall clear-cut rule does not exist to govern them all.

However prostate cancer is essentially a slow growing disease, one that could be incident and growing in a patients organ for year before its first symptoms and outward signs start to show. In men over the age of 70 with early-stage prostate cancer, the disease often progresses so slowly that they are likely to die of other causes before they even develop prostate cancer symptoms. This actually is why several oncologists believe that many patients in this age group can forgo surgery or other treatments as long as their condition is regularly monitored ? a treatment option known as watchful waiting.

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Can I Survive Advanced Prostate Cancer Whats The Prognosis

Prostate cancer is the second leading cause of death from cancer in men, according to the National Cancer Institute. While theres no cure, men can live with it for years if they get the right treatment. Each man with advanced prostate cancer is different, of course. You and your cancer have unique qualities that your doctor takes into consideration when planning the best treatment strategy for you.

According to Harvard Medical School, the prognosis for men with advanced prostate cancer is improving because of newer medications that help them get past a resistance to androgen-deprivation therapy that typically develops after a few years of treatment. With these medications, many men are living longer, and a number of men diagnosed with advanced prostate cancer are dying with the cancer, not from it.

Promptly treating prostate cancer bone metastases with the newest medication can help change a mans prognosis dramatically, Tagawa says. There are men who do well for decades, he says. Some men can even stop treatment, go on to live many years, and actually die of something unrelated.

Tagawa says that cancer specialists who use sophisticated imaging technologies, like positron-emission tomography scans, have gotten very good at finding even tiny bone metastases, which is valuable in diagnosing and removing early stage metastases.

Where Prostate Cancer Spreads

If left untreated, diagnosed prostate cancer can grow and possibly spread outside of the prostate to local tissues or distantly to other sites in the body. The first sites of spread are typically to the nearby tissues.

The cancer can spread down the blood vessels, lymphatic channels, or nerves that enter and exit the prostate, or cancer could erode directly through the capsule that surrounds the prostate.

The seminal vesicles are a site of particularly common early spread. More extensive local spread can occur with cancer invading the nearby bladder or rectum.

Further advancement of cancer can occur when cancer cells enter the blood vessels and lymphatic channels. Once cancer has entered into these vessels, prostate cancer cells can seed into virtually any other part of the body.

Prostate cancer is known to have a particular affinity for spreading or metastasizing to the bones especially the lower spine, pelvis, and femur. Other organs such as the liver, brain, or lungs can also be the sites of spread, but these are much rarer.

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Looking For More Of An Introduction

If you would like more of an introduction, explore these related items. Please note that these links will take you to other sections on Cancer.Net:

• ASCO Answers Fact Sheet:Read a 1-page fact sheet that offers an introduction to prostate cancer. This free fact sheet is available as a PDF, so it is easy to print.

• ASCO Answers Guide:Get this free 44-page booklet that helps you better understand the disease and treatment options. The booklet is available as a PDF, so it is easy to print.

• Cancer.Net Patient Education Video:View a short video led by an ASCO expert in prostate cancer that provides basic information and areas of research.

• Cancer.Net En Español: Read about prostate cancer in Spanish or read a 1-page ASCO Answers Fact Sheet in Spanish. Infórmase sobre cáncer de próstata en español o una hoja informativa de una página, Respuestas sobre el cáncer.

The next section in this guide is Statistics. It helps explain the number of people who are diagnosed with prostate cancer and general survival rates. Use the menu to choose a different section to read in this guide.

ON THIS PAGE: You will find information about the number of people who are diagnosed with prostate cancer each year. You will also read general information on surviving the disease. Remember, survival rates depend on several factors. Use the menu to see other pages.

Statistics adapted from the American Cancer Societyâs publication, Cancer Facts & Figures 2021, and the ACS website .

What Are The Signs Of Prostate Cancer

Most early prostate cancers are detected with PSA tests or digital rectal exams before they cause any symptoms. However, more advanced prostate cancers can cause a variety of symptoms including:

• Trouble starting to urinate .
• Urinating much more often than usual.
• The feeling that you can’t release all of your urine.
• Pain with urination or ejaculation.
• Blood in your urine or semen.
• Impotence/erectile dysfunction.
• Numbness in the lower extremities.
• Loss of bladder or bowel control.

All of these symptoms can be caused by things other than prostate cancer, so experiencing them doesn’t necessarily mean you have prostate cancer. When older men have problems urinating, it is usually caused by a problem called benign prostatic hyperplasia , which is not prostate cancer. If you have any of these symptoms, you need to see your provider for testing.

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Where Does Prostate Cancer Usually Spread First

If prostate cancer spreads to other parts of the body, it almost always goes to the bones first. These areas of cancer spread can cause pain and weak bones that might break. Medicines that can help strengthen the bones and lower the chance of fracture are bisphosphonates and denosumab.

Stages Of Prostate Cancer

In order to determine the stage of a patients prostate cancer, most doctors start by using the TNM staging system, which helps describe different aspects of the cancers growth.

• T the T category measures the size and extent of the Tumor
• N the N category measures whether and how far the cancer has spread to the Lymph Nodes
• M the M category whether the cancer has spread to other organs in the body (a process called Metastasis

The score for each of these categories is determined based on a pre-determined set of criteria. Your doctor cannot feel or see the tumor with a score of T1. A score of T3 means that the tumor has begun to grow outside of the prostate.

After calculating the TNM categories, doctors will combine the TNM score with the patients Gleason score and PSA levels assigning of a specific stage to the patients cancer.

Prostate cancer prognosis and survival rates can help give patients an idea of their chances of surviving the disease based on the stage and time of diagnosis. While some patients may find this information helpful, others may not want to know.

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Drugs To Treat Cancer Spread To Bone

If prostate cancer spreads to other parts of the body, it almost always goes to the bones first. These areas of cancer spread can cause pain and weak bones that might break. Medicines that can help strengthen the bones and lower the chance of fracture are bisphosphonates and denosumab. Sometimes, radiation, radiopharmaceuticals, or pain medicines are given for pain control.

Side effects of bone medicines

A serious side effect of bisphosphonates and denosumab is damage to the jaw, also called osteonecrosis of the jaw . Most people will need to get approval from their dentist before starting one of these drugs.

Signs Of Prostate Cancer

Although prostate cancer is slow growing and can take years for symptoms to appear, men should be periodically checked with a PSA test.

Signs of prostate cancer include trouble urinating, blood in the urine, difficulty getting an erection, and pain in the back, hips, ribs, or other bones.

If a diagnosis is made, treatment will be determined by your age, any other medical issues you may have, the prognosis , and your feelings about the side effects.

Contact Dr. Steven Gange at 993-1800, or request a visit online, for questions concerning your treatment plan, or if you are having any symptoms of prostate cancer.

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Slowest And Fastest Growing Cancer Cells

The cancer cells that comprise more genetic damage tend to grow faster. Whereas, the cancer cells that contain less genetic damage grows slowly. However, you can grade tumors in the following:

• G4: high-grade or undifferentiated
• G3: poor differentiation or high-grade
• G2: intermediate-grade or moderate differentiation
• G1: low-grade or well-differentiated

Few breast cancer such as triple and inflammatory breast cancer

Acute myeloid and lymphoblastic leukemia

What Questions Should I Ask My Healthcare Provider

If you have prostate cancer, you may want to ask your healthcare provider:

• Why did I get prostate cancer?
• What is my Gleason score? What is my Grade Group? What do these numbers mean for me?
• Has the cancer spread outside of the prostate gland?
• What is the best treatment for the stage of prostate cancer I have?
• If I choose active surveillance, what can I expect? What signs of cancer should I look out for?
• What are the treatment risks and side effects?
• Is my family at risk for developing prostate cancer? If so, should we get genetic tests?
• Am I at risk for other types of cancer?
• What type of follow-up care do I need after treatment?
• Should I look out for signs of complications?

A note from Cleveland Clinic

Prostate cancer is a common cancer that affects males. Most prostate cancers grow slowly and remain in the prostate gland. For a small number, the disease can be aggressive and spread quickly to other parts of the body. Men with slow-growing prostate cancers may choose active surveillance. With this approach, you can postpone, and sometimes completely forego, treatments. Your healthcare provider can discuss the best treatment option for you based on your Gleason score and Group Grade.

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Stem Cell Or Bone Marrow Transplant

A stem cell transplant, sometimes called bone marrow transplant, replaces damaged blood-forming cells with healthy ones. The procedure takes place following large-dose chemotherapy or radiation therapy to kill cancer cells and to stop your stem cells from producing cancerous cells.

Stem cell transplants can be used for several types of cancer, including multiple myeloma and some kinds of leukemia.

What Types Of Testing Should I Expect For Monitoring My Condition

Since metastatic prostate cancer isnt curable, your doctor will most likely set up regular visits to check the cancers location, and to manage any long-term side effects from the cancer or any medication youre taking.

And since treatments for advanced prostate cancer are changing so fast and need to be given in a certain sequence to be the most effective, youll probably have not only a prostate cancer doctor but other specialists taking care of you. Your care team should coordinate closely, say the authors of a major study of such teams published in August 2015 in the journal Annals of Oncology.

Along with regularly testing your prostate-specific antigen levels, your care team may request blood tests that measure such prostate cancer indicators as alkaline phosphatase and lactate dehydrogenase. Magnetic resonance imaging or PET scans of the spine or other bones can also help identify how your cancer responds to treatment.

If youve had radiation, youre at an increased risk for bladder and colorectal cancer and should get screened regularly for these as well.

The tests youll have and how often youll need them should be customized to you. Your care team will consider your overall health, medications that are safe for you to take, other health conditions you might have, and what stage your cancer was when you were diagnosed.

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Receiving Treatment For Prostate Cancer That Has Spread

At Moffitt Cancer Center, the experts within our Urologic Oncology Program treat patients with all stages of prostate cancer, including advanced-stage cancers that have metastasized to other areas of the body. Our multispecialty team collaborates as a tumor board, ensuring each patient receives a treatment plan tailored to his unique needs. For individuals with metastatic prostate cancer, treatment plans aim to alleviate symptoms, slow the rate of cancer growth and shrink tumors to help improve quality of life.

If Prostate Cancer Spreads

Cancer cells can spread from the prostate to other parts of the body. This spread is called metastasis.

Understanding how a type of cancer usually grows and spreads helps your healthcare team plan your treatment and future care. If prostate cancer spreads, it can spread to the:

• bladder
• urethra
• ejaculatory ducts
• seminal vesicles
• rectum
• lymph nodes in the pelvis
• lymph nodes outside the pelvis

• American Joint Committee on Cancer. AJCC Cancer Staging Handbook. 7th ed. Chicago: Springer 2010.
• Brierley JD, Gospodarowicz MK, Wittekind C . TNM Classification of Malignant Tumours. 8th ed. Wiley Blackwell 2017.
• Hermanns T, Kuk C, Zlotta AR. Clinical presentation, diagnosis and staging. Nargund VH, Raghavan D, Sandler HM . Urological Oncology. Springer 2015: 40: 697-718.
• National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Prostate Cancer . .
• Scher HI, Scardino PT, Zelefsky. Cancer of the prostate. DeVita VT Jr, Lawrence TS, Rosenberg SA. Cancer: Principles and Practice of Oncology. 10th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins 2015: 68:932-980.

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Quality Of Life With Advanced Stage Prostate Cancer

Since Huggins and Hodges won a Nobel Prize in 1966 for their work describing the relationship between testosterone and prostate cancer, androgen deprivation has continued to be an important component in the treatment of advanced prostate cancer. It is associated, however, with significant cost in terms of morbidity as well as economics. Side effects of androgen deprivation therapy include hot flashes, osteoporosis, loss of libido or impotence, and psychological effects such as depression, memory difficulties, or emotional lability. Recently Harle and colleagues reported insulin resistance, hyperglycemia, metabolic syndrome, and metabolic complications being associated with castration and thus being responsible for increased cardiovascular mortality in this population.

Because of the palliative nature of androgen ablation, quality of life is an important component of evaluating competing therapies. Intermittent androgen deprivation is one approach to hormonal therapy that has been developed with the aim of minimizing the negative effects of therapy while maximizing clinical benefits and the patients quality of life. It can be used in any clinical situation where continuous androgen deprivation treatment could be applied.

Side Effects Of Prostate Surgery

The major possible side effects of radical prostatectomy are urinary incontinence and erectile dysfunction . These side effects can also occur with other forms of prostate cancer treatment.

Urinary incontinence: You may not be able to control your urine or you may have leakage or dribbling. Being incontinent can affect you not only physically but emotionally and socially as well. These are the major types of incontinence:

• Men with stress incontinence might leak urine when they cough, laugh, sneeze, or exercise. Stress incontinence is the most common type after prostate surgery. It’s usually caused by problems with the valve that keeps urine in the bladder . Prostate cancer treatments can damage this valve or the nerves that keep the valve working.
• Men with overflow incontinence have trouble emptying their bladder. They take a long time to urinate and have a dribbling stream with little force. Overflow incontinence is usually caused by blockage or narrowing of the bladder outlet by scar tissue.
• Men with urge incontinencehave a sudden need to urinate. This happens when the bladder becomes too sensitive to stretching as it fills with urine.
• Rarely after surgery, men lose all ability to control their urine. This is called continuous incontinence.

After surgery for prostate cancer, normal bladder control usually returns within several weeks or months. This recovery usually occurs slowly over time.

There are several options for treating erectile dysfunction:

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Gleason Prostate Cancer Score

1960s as a way to measure how aggressive your prostate cancer may be.

A pathologist determines your Gleason score by looking at a biopsy of your prostate tissue under a microscope. They grade the cells in the biopsy on a scale of 1 to 5. Grade 1 cells are healthy prostate, whereas grade 5 cells are highly mutated and dont resemble healthy cells at all.

The pathologist will calculate your Gleason score by adding together the number of the most prevalent type of cell in the sample and the second most prevalent type of cell.

For example, if the most common cell grade in your sample is 4 and the second most common is 4, you would have a score of 8.

A Gleason score of 6 is considered low-grade cancer, 7 is intermediate, and 8 to 10 is high-grade cancer.

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Stages In Spread Of Cancer

Cancers are categorized based upon their tumor size and how long does it take cancer to spread during diagnosis. This is the time that your doctor decides the course of treatment along with providing general information. Below are the few stages of cancer.

• Unknown: Few information to determine the stage.
• Distant It has started moving along with affecting far located tissues and organs.
• Regional Cancer has started to spread to nearby organs, lymph nodes, and tissues.
• In situ This is referred to as the precancerous stage where it has not started its spreading to nearby body parts.

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