Which Is The Best Form Of Vitamin C
Vitamin C comes in two forms ascorbic acid and ascorbate. Ascorbic acid is mildly acidic and ascorbate is alkaline. If you are taking in high amount my preference is an alkaline balanced combination of the two roughly 50:50.
Ascorbate forms of vitamin C have to be bound to a mineral to be stable. This could be calciumWhat it does: Promotes a healthy heart, clots blood, promotes healthy nerves, contracts muscles, improves skin, bone and dental health, relieves aching muscles and bones,, magnesiumWhat it does: Strengthens bones and teeth, promotes healthy muscles by helping them to relax, also important for PMS, important for heart muscles and nervous, potassiumWhat it does: Enables nutrients to move in and waste products to move out of cells, promotes healthy nerves and muscles, maintains fluid balance in, sodium, zincWhat it does: Component of over 200 enzymes in the body, essential for growth, important for healing, controls hormones, aids ability to cope with stress or manganeseWhat it does: Helps to form healthy bones, cartilage, tissues and nerves, stabilises blood sugar, promotes healthy cells, essential for reproduction and red blood cell. These minerals have other benefits and potential downsides at high doses. Sodium ascorbate, in high doses, adds to the sodium load and is not good if, for example, you have hypertensionHypertension is more commonly known as high blood pressure..
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Vitamin C And Base Infusions Prostate Cancer Treatment
Patients suffering from prostate cancer should receive a combination of Vitamin C and base infusions. The base infusions reduce the hyperacidity of the tumour, and the painful and irritated tissue is relieved and can regenerate.
At the Alternative Cancer Treatment Centre in Kehl, Dr. Hartung combines Vitamin C with base infusions in the treatment of prostate cancer.
Vitamin C And Dca Prostate Cancer Treatment
Patients that suffer from prostate cancer can be treated very well with a combination of Vitamin C and DCA .
The functioning of the mitochondria in the prostate cancer cells is impaired. DCA can normalise the mitochondrial function and induce apoptosis. This inhibits cell proliferation and slows down tumour growth.
At the Alternative Cancer Treatment Centre in Kehl, Dr. Hartung combines the Vitamin C therapy with DCA therapy in the treatment of prostate cancer.
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Questions And Answers About Intravenous Vitamin C
Vitamin C is a nutrient that is found in food, such as oranges, grapefruit, kiwi, peppers, and broccoli, and in dietary supplements. Vitamin C is an antioxidant and helps prevent damage to cells caused by free radicals. It also works with enzymes to play a key role in making collagen. Vitamin C is also called L-ascorbic acid or ascorbate.
Vitamin C may be given by intravenous infusion or taken by mouth. When given by IV infusion, vitamin C can reach much higher levels in the blood than when it is taken by mouth.
In laboratory studies, tumor cells are used to test a substance to find out if it is likely to have any anticancer effects. In animal studies, tests are done to see if a drug, procedure, or treatment is safe and effective. Laboratory and animal studies are done in animals before a substance is tested in people.
Laboratory and animal studies have tested the effects of IV vitamin C. Laboratory studies suggest that high levels of vitamin C may kill cancer cells. For information on laboratory and animal studies done using intravenous vitamin C, see the Laboratory/Animal/Preclinical Studies section of the health professional version of Intravenous Vitamin C.
Changes To This Summary
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
This summary was comprehensively reviewed.
This summary is written and maintained by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ® – NCI’s Comprehensive Cancer Database pages.
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Q4 Does Ivc Interfere With Chemotherapy Or Radiotherapy
Potential interactions between vitamin C and chemotherapeutic agents have long been a matter of debate . Because of vitamin Cs potent antioxidant activity, many clinicians believe they have to avoid the concurrent use of IVC during all chemotherapy regimens. However, different chemotherapeutic agents act via different mechanisms, and only some act via oxidative mechanisms . Nevertheless, it has been recommended for administered natural therapies to allow five half-lives to elapse prior to administration of chemotherapeutic agents to eliminate potential interactions . Because vitamin C has a relatively short half-life of < 2 h in circulation due to rapid renal clearance, IVC is typically administered the day before or after chemotherapy administration . However, if the chemotherapeutic agent does not act via oxidative mechanisms, then concurrent IVC administration may not be an issue and would be more patient centered.
TABLE 4. Summary of the effects of high-dose vitamin C administration in pre-clinical cancer models.
TABLE 5. Summary of the effects of IVC administration in clinical studies.
I Generation Of Hydrogen Peroxide
Currently, one of the most widely accepted anti-cancer mechanisms proposed for vitamin C is based on its so-called pro-oxidant activity . However, this terminology can be misleading as vitamin C itself always acts as an antioxidant, through donation of electrons the pro-oxidant action occurs subsequently and is therefore an indirect effect. As such, the term pro-drug has been adopted by some researchers . In vitro, vitamin C is able to reduce transition metal ions, such as ferric and cupric cations, which are present in buffers or in cell culture media. The reduced transition metal ions are then able to generate hydrogen peroxide through reduction of oxygen to the superoxide radical, which can react with itself to form hydrogen peroxide. However, whether catalytically available transition metal ions are found in vivo and can cause enhanced oxidative stress is still a matter of some debate since iron and copper are normally sequestered in transport and storage proteins such as transferrin, ferritin and ceruloplasmin . Nevertheless, in some pathological situations, such as iron and copper-overload diseases and during tissue injury, free transition metal ions may become more catalytically available . It has also been postulated that transition metal ions are catalytically more available in the extracellular fluid of the tumor microenvironment .
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Hrqol And Ecog Performance Status
Sixteen patients had an unchanged ECOG score at week 12 2 patients had an improved score, and 2 had a worse score, with a drop of 12 steps. Table 7 shows the HRQoL data. Only 1 scale, physical functioning, differed from baseline to week 12, and no trends of improvement were seen for the other scales.
Excess Iron Abrogates The Inhibitory Effect Of Vc On K562 Cell Growth In Vivo
We next examined the impact of excess iron on the effect of VC on K562 cell growth in vivo using an experimental transplantation model. On day 0, we transplanted a mixture consisting of Luc-K562 cells and basement membrane matrix subcutaneously into the right flank of NOD/SCID mice. From day 7 after transplantation, we injected the vehicle, VC , saccharated ferric oxide , or both VC and SFO into the mice for a total of 12 days, and measured tumor sizes on day 23 after transplantation. Bioluminescence imaging of Luc-K562 cells in the mice was also performed. We also measured general toxicity during the experiment, and we did not detect obvious behavioral change, morbid consumption such as significant weight loss, or death of mice. On day 23, tumor growth was significantly suppressed in the mice injected with VC, compared to mice injected with vehicle or SFO . However, tumor growth was significantly enhanced in the mice injected with both VC and SFO . We did not detect newly developed tumors other than the tumors initially transplanted, or invasion of the leukemic cells to other organs, including the bone marrow and peripheral blood, of all mice.
Figure 3
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Q7 What Are The Optimal Doses Frequency And Duration Of Ivc Therapy
Intravenous vitamin C has been used for decades by health care professionals with very little consistency in the dose, frequency, or duration of use. A survey of complementary and alternative medicine practitioners showed an average dose of 28 g/infusion , a frequency of approximately twice a week , and about 19 treatments per patient . Because of the prevailing pro-oxidant paradigm of IVC, it is generally believed that more is better and doses as high as 200 g/infusion have been administered to oncology patients . Lower IVC doses of 2.510 g/infusion have been shown to decrease common cancer- and chemotherapy-related symptoms and improve health-related quality of life .
The Truth About Vitamin C And Cancer
Vitamin CWhat it does: Strengthens immune system fights infections. Makes collagen, keeping bones, skin and joints firm and strong. Antioxidant, detoxifying pollutants and protecting against, especially in large amounts, is one of the most effective natural and non-toxic ways to both prevent and treat several kinds of cancer. See the latest compelling evidence.
First shown to be a powerful anti-cancer agent in 1971, it wasnt until the 90s that vitamin CWhat it does: Strengthens immune system fights infections. Makes collagen, keeping bones, skin and joints firm and strong. Antioxidant, detoxifying pollutants and protecting against started to be accepted by the mainstream medical profession as having a role in cancer prevention. Eating a vitamin C-rich diet substantially reduces the risk of several cancers, and high intakes above 5,000mg a day substantially increases the life expectancy of cancer patients.
Approximately 90 epidemiologic studies have examined the role of vitamin C or vitamin-C-rich foods in cancer prevention, and the vast majority have found statistically significant protective effects. Evidence is strong for ¬cancers of the oesophagus, oral cavity, stomach and pancreas. There is also substantial evidence of a protective effect in cancers of the cervix, rectum and breast. Even in lung cancer there is recent evidence of a role for vitamin C.
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Can Vitamin C Help Prostate Cancer
Prostate cancer is a widespread malignancy. The rates spike after the age of 50 and are the highest in men over 90.
To amplify the results of prostate cancer treatment, many are looking to use natural alternatives for prostate cancer. Can vitamin C be of use and mitigate the prostate cancer risk?
One meta-analysis indicates that consuming vitamin C from your diet might be inversely associated with the risk of prostate cancer.
Experts found a 9% reduction in risk of prostate cancer for each 150 mg/day increment. This suggests that vitamin C from food could prevent the onset of prostate carcinoma. But, more data is necessary to evaluate the role of this vitamin on cancer cells.
Another case report showed a beneficial impact of high doses of vitamin C for the treatment of prostate adenocarcinoma. Earlier reports of IV vitamin C stated that this vitamin improved the symptoms of cancer. And prolonged life in terminally ill patients.
Further data indicate that after 10 months of IVC therapy, the vascular tumor present on the left section of the prostate was no longer detectable with ultrasound. Although data on IVC treatment on total cancer is limited, this evidence might indicate that vitamin C has some anti-tumor activity.
According to 2018 reports, experts didnt find an association between vitamin C consumption and overall prostate cancer. Based on these findings, the vitamin doesnt seem to have the potential for prostate cancer prevention.
The Controversial History Of High
Utilizing high doses of vitamin C as a cancer therapy is no exception to this controversy. Nearly 60 years ago Toronto physician William McCormick observed that cancer patients often presented with severely low levels of vitamin C in their blood and featured scurvy-like symptoms, leading him to postulate that vitamin C might protect against cancer by increasing collagen synthesis. In 1972, extending this theory, Ewan Cameron, a Scottish surgeon, hypothesized that ascorbate could suppress cancer development by inhibiting hyaluronidase, which otherwise weakens the extracellular matrix and enables cancer to metastasize. He began treating terminally ill cancer patients and published a case report of 50 patients in which some of the treated patients benefited from high dose vitamin C.
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Evaluation Of Cam Therapies
It is important that the same scientific methods used to test conventional therapies are used to test CAM therapies. The National Cancer Institute and the National Center for Complementary and Integrative Health are sponsoring a number of clinical trials at medical centers to test CAM therapies for use in cancer.
Conventional approaches to cancer treatment have generally been studied for safety and effectiveness through a scientific process that includes clinical trials with large numbers of patients. Less is known about the safety and effectiveness of complementary and alternative methods. Few CAM therapies have been tested using demanding scientific methods. A small number of CAM therapies that were thought to be purely alternative approaches are now being used in cancer treatmentnot as cures, but as complementary therapies that may help patients feel better and recover faster. One example is acupuncture. According to a panel of experts at a National Institutes of Health meeting in November 1997, acupuncture has been found to help control nausea and vomiting caused by chemotherapy and pain related to surgery. However, some approaches, such as the use of laetrile, have been studied and found not to work and to possibly cause harm.
High Dose Vitamin C Helps Other Treatments Become Less Toxic
There is a general concern among doctors that high dose vitamin C will somehow interfere with chemotherapy or radiotherapy. Most studies that have tested the safety of high dose vitamin C have reported that patients feel better and that if vitamin C is given alongside chemotherapy or radiation therapy, there are less side-effects.
A good example of this was a study in Germany, where 53 out of 125 breast cancer patients were given IV vitamin C alongside chemotherapy. Those having simultaneous vitamin C therapy reported less than half the intensity of side-effects in particular of nausea, loss of appetite, fatigue, depression, sleep disorders, dizziness and haemorrhagic diathesis, concluded the researchers. No side-effects of the IV vitamin C administration were documented.
Given that vitamin C is an antioxidant some doctors are reluctant to give high dose vitamin C, even though it acts as a pro-oxidant within cancer cells if you get the level high enough, alongside radiation treatment. This concern, however, may not be justified.
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How Vitamin C Works Antioxidant And Pro
Of all the antioxidants, vitamin C is the most extraordinary. Vitamin C is believed to help prevent and treat cancer by enhancing the immune system stimulating the formation of collagen which is necessary for walling off tumours preventing metastasis by inhibiting a particular enzyme and therefore keeping the ground substance around tumours intact preventing viruses that can cause cancer correcting a vitamin C deficiency which is often seen in cancer patients speeding up wound healing in cancer patients after surgery enhancing the effectiveness of some chemotherapy drugs as well as radiation therapy reducing the toxicity of some chemotherapy preventing free radical damage and neutralising some carcinogens.
However, at high doses, vitamin C starts to act as a pro-oxidant. The discovery that, in high doses, it acts like a pro-oxidant specifically within cancer cells but not in normal cells opens up a new avenue of understanding for the potential value of mega-dose vitamin C since many chemotherapy drugs are pro-oxidants thats how they weaken cancer cells.
Reduction Of Body Iron Stores Shows A Synergistic Effect With Vc On The Growth Inhibition Of K562 Cells In Vivo
Accordingly, we next examined the effect of VC on the growth of K562 cells using NOD/SCID mice with an iron deficiency caused by low iron feed, phlebotomy, and oral DFX. The decrease in the amount of stored body iron was confirmed by measuring the serum ferritin level . The mice were then transplanted with Luc-K562 cells and injected with vehicle or VC from day 7 for a total of 12 days, and the tumor volumes were measured on day 23 after transplantation. Bioluminescence imaging of Luc-K562 cells in the mice was also performed. We did not detect obvious behavioral change, morbid consumption such as significant weight loss, or death of mice during the experiment. On day 23, in mice injected with vehicle, tumor growth was significantly inhibited in mice that had reduced iron, indicating that along with VC, body iron reduction also inhibited the leukemic cell growth . Furthermore, in mice treated with VC, tumor growth was significantly inhibited in mice that had reduced iron, indicating that VC administration and a reduction in body iron synergistically inhibited the leukemic cell growth . We did not detect other developed tumors or invasion of the leukemic cells to other organs in all mice.
Figure 6
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