If You Need Information About Innovative Psma Therapy With Lutetium
In Germany, prostate cancer is treated in large multidisciplinary university hospitals with urology and oncology departments, as well as specialized centers of prostate cancer treatment and radiation therapy. The availability of robotic surgical systems, HIFU equipment, devices for three-dimensional conformal radiation therapy, drugs for androgen blockade and symptomatic therapy and other innovative resources allows specialists to choose exactly the right therapeutic regimen that will be most effective for a particular patient. The latest technique that has been successfully used in the treatment of metastatic prostate cancer is Lutetium-177 therapy. Lu-177 PSMA is unique among other cancer treatments because it targets prostate cancer loci regardless of its location in the body .
Targeted Therapy And Immunotherapy
For targeted therapy for prostate cancer, PARP inhibitors are used. They are prescribed only to patients with BRCA gene mutations. The drugs block the ability of tumor cells to repair damaged DNA. These drugs are usually used when hormone therapy and chemotherapy are not effective enough.
Immunotherapy for prostate cancer is carried out with the following medications:
- sipuleucel-T prostate cancer vaccine
- immune checkpoint inhibitors.
The cancer vaccine is made for each patient individually. Doctors take immune cells from their blood. These are then sent to a laboratory, where they are mixed with prostatic acid phosphatase . The white blood cells are then injected back into the body. Then, they are able to recognize and attack the tumor. The procedure is carried out once every 2 weeks. In total, the vaccine is administered 3 times. It does not cure cancer, but increases the life expectancy of patients by several months.
PD-1 inhibitors work by enhancing antitumor immunity. They block proteins that help the tumor evade the immune response. These drugs are used only for high levels of microsatellite instability , or changes in one of the mismatch repair genes. Medicines are administered intravenously, once every 2-3 weeks.
A Safe Treatment With Almost No Side Effects
The dendritic cells processed in the laboratory are tested for absolute purity and injected into the patient only after thorough molecular biological analysis in accordance with the requirements of the German Drug Law.
Only tumour cells and no healthy cells are attacked during this treatment, which is why only minor side effects occur.
For example, a slight fever, which can be quickly controlled with a paracetamol tablet.
Many studies prove the harmlessness of this type of immunotherapy.
The injection of the individually produced, activated dendritic cells into the patients body is completely harmless.
The reasons for this:
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Why Choose Qunomedical For Your International Medical Needs
Millions of Americans travel to other countries for their medical needs each year. There are many reasons why.
One factor is that treatment may cost less in other countries compared to the United States. This may be a more significant driving factor in recent years, as almost 5.4 million Americans lost their health insurance during the Coronavirus pandemic a record high.
Many people also seek procedures or therapies first approved in other countries before becoming available in the United States.
Planning for medical treatment abroad can be difficult. How do you know where to start? Where do you find qualified medical professionals that fit your medical needs? How do you manage hospital stays, pricing, and travel plans while you may be suffering from pain, fatigue, and other issues?
Founded by a medical professional, Qunomedical offers a concierge approach to high-quality and affordable medical treatments abroad. Every month, we connect over 6,500 patients with professionally-vetted doctors around the world. We offer 24/7 personalized support and everything you need to make an informed decision. Get your free assessment here.
What Are The Symptoms Of Prostate Cancer
Around 60,000 men get prostate cancer every year in Germany. In most cases, the disease is detected at an early stage, when patients do not normally have any symptoms. Even if the condition is more advanced, patients frequently do not have typical symptoms. This means that the symptoms they have could also be caused by other illnesses.
The symptoms of prostate carcinoma may include:
- difficulty urinating the bladder cannot be spontaneously emptied
- discomfort when urinating
- blood in the urine or seminal fluid
- difficulties during sex
Difficulty urinating often occurs as men get older. This is because the prostate gets bigger with age and presses on the urethra. This benign enlargement of the prostate is known by medical practitioners as benign prostatic hyperplasia .
If the symptoms persist over several weeks, a visit to the doctor is recommended. The doctor can start narrowing down what is causing the symptoms and, if necessary, initiate further diagnostic steps by specialists.
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Rehabilitation After Prostate Cancer Treatment
After treatment of complex oncological diseases, most patients require rehabilitation. It includes the following aspects:
- Prevention of complications that may occur as a result of treatment. It can be pneumonia, lymphostasis, thromboembolic, or infectious complications.
- Restoration of general health. The elimination of the consequences after surgeries and chemotherapy is carried out. The functions of internal organs are restored with the help of various medical and rehabilitation measures.
- Restoration of occupation. A person must not just stay alive. He must have physical and intellectual capabilities, which are sufficient for employment.
- Psychological support. First of all, it is required for patients, whose occupational performance was harmed because of the disease. Patients with deterioration of appearance also will benefit from psychological help.
- Restoration of appearance. If necessary, you can use surgical and other methods in Germany to restore the appearance defects caused by cancer. For example, to carry out the reconstruction of the breast.
- Social and domestic rehabilitation. A person with reduced workability is trained to act in society and perform everyday tasks in new conditions.
In Germany, rehabilitation is carried out with the maximum comfort for the patient. A person feels the results quite quickly and it improves his motivation and promotes further recovery.
The Course Of Treatment And The Costs
Before starting therapy, the medical records are reviewed by the doctors at the clinic. This can take place during an initial consultation at the clinic or via teleconference with the patient. A blood test is required to check the immune system and tumour activity. This can be done at the clinic or at the patients home in an appropriately trained laboratory.
This is followed by the development of the therapy strategy until this is ready it takes about 2 weeks.
First therapy unit – first vaccination cycle
Duration: 8 days
This starts with the blood collection see treatment procedure dendritic cells-.
Unlike dendritic cell therapy where patients go home between blood collection and injection of activated cells, patients stay at the clinic. For 8 days. During this time, the virus is administered, combined with hyperthermia applications, vitamins and trace elements.
The Second Therapy Unit- Second Vaccination Cycle
Duration 8 days
This is a second cycle with the dendritic cells, the virus administration and hyperthermia plus vitamins and trace elements.
After 3 weeks the success of the vaccination is examined
Costs can be different for each patient, as the therapy offer is tailored to each individual patient.
As a guideline:
Cost of laboratory tests:
- these can be done locally in most countries and will probably be covered by health insurance: EUR 4000 to EUR 7000
- Costs per vaccination cycle therapy unit: about EUR 28000
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Treatment Of Gastric Cancer In Germany
Causes of Gastric Cancer
Symptoms of Gastric Cancer
- Stomach discomfort and indigestion
- Loss of appetite
- Discomfort in the middle or upper part of the stomach
- Blood in the stool
- Vomiting blood or simply vomiting
- Fatigue or weakness due to mild anemia
- Bloating or pain in the stomach after consuming meals
Diagnosis of Stomach Cancer
Oncology in Germany
Treatment of Gastric Cancer in Germany
cancer treatment in Germany
Chemotherapy for Gastric Cancer
Radiation Therapy for Gastric Cancer
treatment of gastric cancertreatment of gastric cancer in Germany
Hormone Therapy And Chemotherapy
The most common treatment for metastatic prostate cancer is hormone therapy. It provides long-term control of the tumor and metastatic foci.
Preference is given to medical drugs luteinizing hormone-releasing hormone antagonists. However, when treated with these drugs, the symptoms often become more severe, and only after a while do they weaken. Therefore, at the early stage of therapy, antiandrogens are used, since they work faster.
The second most common treatment for prostate cancer with metastases, is chemotherapy. It can be combined with hormone therapy. Some patients receive chemotherapy only after hormone treatment for prostate cancer has become ineffective.
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Advanced Prostate Cancer Treatment In Germany: Focus On Curative Procedures
While early-stage prostate cancer has a beneficial prognosis and a 5-year relative survival rate of 100%, more effort is needed to cure the disease at a late stage. In addition to the conventional techniques, advanced prostate cancer treatment in Germany includes PSMA therapy with Lutetium-177 and Actinium-225, as well as innovative nonsteroidal antiandrogen medicine Xtandi .
While the early-stage prostate cancer has the beneficial prognosis and 5-year relative survival rate of 100%, more effort is needed to cure the disease at a late stage. In addition to the conventional techniques, advanced prostate cancer treatment in Germany includes PSMA therapy with Lutetium-177 and Actinium-225, as well as innovative nonsteroidal antiandrogen medicine Xtandi .
Nanoknife Is A Pioneering Treatment For Prostate Cancer The First Nerve Sparing Prostate Cancer Treatment
Unlike traditional prostate cancer treatments, NanoKnife kills the prostate cancer cells instead of removing or irradiating the entire prostate. Its a one time two hour procedure, at most. Not weeks. Not months. Youre clear in days, with no side effects no incontinence, no impotence.*
Talk to us here at Vitus and youre talking to the worlds leading experts in using NanoKnife for treating prostate cancer, with over 1000 mentreated successfully.
*No incontinence in any of the patients we have treated with NanoKnife. No impotence in 90-95%.
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Puret Et Qualification Maximales En Laboratoire
La production dune « préparation cellulaire » avec des cellules dendritiques est soumise à la loi allemande sur les médicaments pour les thérapies avancées. Elle ne peut être effectuée que dans un laboratoire spécial officiellement agréé, de la plus haute classe de qualité et doté dun équipement complet. (Laboratoire conforme à la loi allemande sur les médicaments et aux directives européennes BPF bonnes pratiques de fabrication.
Des employés hautement qualifiés sont indispensables. Ils produisent la préparation cellulaire selon les réglementations les plus strictes et sous le contrôle du célèbre Institut Paul Ehrlich. Le laboratoire en salle blanche doit être absolument exempt de germes, ce qui est obtenu par une surpression et un verrouillage du personnel, où les cellules se développent à la température du corps dans des fluides nutritifs spéciaux.
A New Treatment For Advanced Prostate Cancer Improves Survival In Phase 3 Clinical Trial
- By Charlie Schmidt, Editor, Harvard Medical School Annual Report on Prostate Diseases
Radiation therapy is getting more precise, enabled by technologies that make it easier to kill tumors while sparing their surrounding tissues. Some newer therapies are even given intravenously instead of by machines, and they deliver radiation particles directly to the cancer cell itself. One of these new therapies a sort of smart bomb targeted at malignant cells is now generating promising data for men with the most aggressive prostate cancer.
In early June, investigators reported results from a phase 3 clinical trial showing that among men who received the experimental treatment, there was nearly a 40% reduction in deaths over the course of the study, compared to men who did not.
The treatment is called lutetium-177-PSMA-617, or LuPSMA, and it has two components: a compound that targets a cancer cell protein called prostate-specific membrane antigen, or PSMA, and a radioactive particle that destroys the cells. Healthy prostate cells donât contain PSMA, or do at very low levels. And some men with prostate cancer have more of the protein than others. Doctors can detect the protein using a specialized imaging scan.
Results after 21 months showed that cancer progression was delayed for longer among the LuPSMA-treated men: 8.7 months on average versus 3.4 months among the controls. The treatment was also associated with better overall survival: 15.3 months versus 11.3 months.
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Predictors Of Hormonal Therapy Use Among Hrlpca Cases Treated By Radiotherapy
Table presents the univariable and multivariable regression results. The multivariable log-binomial model identified that locally advanced PCa cases compared to the poorly differentiated cases were associated with increased use of HT. For every 10-year increase in the patients age, there was a slight increase in the use of HT .
Table 2 Clinical and socio-demographic factors associated with HT use among poorly differentiated and locally advanced PCa cases which received RT between 2005 and 2014
Based on the German Index for Socioeconomic-Deprivation classification, HRLPCa cases from medium , and least affluent residential areas had decreased HT use compared to those from the most affluent areas .
The model from the sensitivity analysis, based on the seven German states, generally showed similar results demonstrating the robustness of the main estimates . Compared to Schleswig-Holstein, the use of HT was lower in Berlin and Thuringia .
Additional file shows that higher age was inversely associated with non-treatment in both the poorly differentiated , and locally advanced cases patients were less likely to undergo treatment the older they were, regardless of how sick they were. Poorly differentiated cases diagnosed during the guideline-era were 1.42 times more likely to risk of non-treatment, compared with cases diagnosed before the guideline-era, but no evidence of a strong association was observed for the locally advanced cases .
Prostate Cancer Treatments In Germany
In Germany, prostate cancer is treated in large multidisciplinary University Hospitals, which have the Departments of Urology and Oncology, as well as in specialized Competence Centers for treatment of prostate cancer and radiation therapy. The availability of robotic surgical systems, HIFU equipment, devices for 3D conformal…
Due to the difficulties associated with the treatment organization in Turkey, Switzerland, South Korea, and India, we are not currently processing requests to these regions.
If you are interested in treatment in Germany, please leave a request, and our specialists will contact you as soon as possible.
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Tape : Chargement Des Cellules Avec Des Informations
Les cellules dendritiques reçoivent les informations nécessaires sur les cellules cancéreuses : Elles sont mises en contact dans le tube à essai avec des protéines de cellules tumorales tuées et spécialement traitées par le patient. Les cellules dendritiques reçoivent ainsi des informations qui leur permettent de reconnaître ultérieurement les cellules cancéreuses dans l’organisme.
Treatment Of Prostate Cancer In Clinics In Germany
- Da Vinci’s robot-assisted surgical system – this equipment of the German clinics of the Vivantes network makes it possible to completely remove malignant neoplasms, reduces blood loss, and minimizes the risk of postoperative complications.
- Advanced Linear Accelerators – The Essen University Hospital is equipped with the latest radiation therapy equipment to destroy abnormal prostate cancer cells without harming healthy tissues and organs.
- Intrabeam is a system that is used in clinics in Germany to effectively destroy cancer cells that remain at the site of complete or partial removal of the tumor, which can significantly reduce the likelihood of recurrence of prostate cancer.
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Da Vinci Robotic Surgery System
The system provides a surgeon with precise tiny instruments to manage surgery with maximal safety and accuracy. A surgeon manipulates on a special console, observing the operated area on 3D images in real-time. The tiny instruments make accurate incisions excluding the trembling hand effect and wrong movements.
Da Vinci robotic system is used as an alternative to open surgery to reduce pain, bleeding, minimize risks of infection and trauma of healthy tissues. An operation is performed through several 1cm incisions, not a big one 15 cm in size as for open surgery. Due to this, a patient recovers faster compared to traditional surgery: within 2-3 weeks instead of several months.
A team of clinicians examined 1,500 men with different prostate cancer stages who had had robotic-assisted prostatectomy. In a 1-year follow-up, 91.9% experienced a normal urinary continence, without any safety pads. 55.3% of men preserved an erectile function and were capable of leading a sexual life. Some postoperative complications in a 3-month follow-up were observed in 8.5% of men.
Treatment Of Prostate Cancer In German Hospitals
Statistics of the World Health Organization demonstrates that prostate cancer is the most common type of oncology in European men. Initiated timely, therapy of the early disease stages leads to almost 100% 5-year survival rate.
Statistics of the World Health Organization demonstrates that prostate cancer is the most common type of oncology in European men. Initiated timely, therapy of the early disease stages leads to almost 100% 5-year survival rate. Unfortunately, used widely PSA blood test cannot guarantee early cancer detection in all cases. That is why more accurate tests Progensa, phi, and 4Kscore are applied in Germany. Conventional prostate cancer treatment in Germany is supplemented with Lutetium-177 and Actinium-225 PSMA therapy, robotic surgical techniques, and immunotherapeutic methods.
The most informative diagnostic procedures
In the most beneficial prognostically case, the disease is revealed during the screening examination with a prostate-specific antigen blood test or a digital rectal examination . These are the most easy-to-perform and cost-effective procedures.
DRE is a direct manual palpation of the prostate gland via the rectum. The procedure does not require any equipment, just a pair of medical gloves.
The PSA blood test may be indicative of the prostate cancer in men without any complaints. If the PSA level exceeds 10, chance of having prostate malignancy is over 50%. Men with high PSA level require further tests, including:
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